Steroids and derivatives
Medchemexpress LLC Glepaglutide acetate | 99.5% | 4376.06 | 5 MG
Glepaglutide acetate is a long-acting GLP-2 analogue and a potent GLP-2R agonist. It functions by reducing faecal output and increasing intestinal absorption. This compound also helps in alleviating small intestinal inflammation, making it suitable for research applications in inflammatory bowel disease (IBD) and Crohn's disease.
- Long-acting GLP-2 analogue
- Potent GLP-2R agonist
- Reduces faecal output
- Increases intestinal absorption
- Alleviates small intestinal inflammation
- Suitable for inflammatory bowel disease (IBD) research
- Suitable for Crohn's disease research
Medchemexpress LLC β-Estradiol 17-hemisuccinate | 7698-93-3 | 98.8% | 372.45 | 1 MG
β-Estradiol 17-hemisuccinate is a synthetic derivative of estradiol, classified as a drug derivative. It is intended for research applications.
- Synthetic derivative of estradiol
- Molecular formula: C22H28O5
- Molecular weight: 372.45
- Purity: 98.83% (LCMS)
- Appearance: White to off-white solid
- Storage: 4°C, stored under nitrogen
- Storage in solvent: -80°C for 6 months; -20°C for 1 month (stored under nitrogen)
Medchemexpress LLC Estra-1,3,5(10)-triene-3,17-diol (17β)-, 17-(hydrogen butanedioate) | 7698-93-3 | 98.8% | 372.45 | 50 MG
β-Estradiol 17-hemisuccinate is a synthetic derivative of estradiol, appearing as a white to off-white solid.
- Synthetic derivative of estradiol.
- CAS number: 7698-93-3.
- Molecular weight: 372.45.
- Chemical formula: C22H28O5.
- Purity: 98.8%.
- Store at 4°C, stored under nitrogen.
- Store in solvent at -80°C for 6 months or -20°C for 1 month, stored under nitrogen.
- 1H NMR spectrum and LCMS consistent with structure.
Medchemexpress LLC Bazedoxifene (acetate)-D | 198481-33-3 | 99.9% | C32H38N2O5 | 50 MG
Bazedoxifene (acetate)-D is the D-crystal form compound of Bazedoxifene acetate, an orally active, nonsteroidal selective estrogen receptor modulator (SERM) with IC50s of 23 nM for ERα and 99 nM for ERβ.
- D-crystal form compound
- Orally active, nonsteroidal selective estrogen receptor modulator (SERM)
- IC50s of 23 nM for ERα and 99 nM for ERβ
- Purity of 99.9%
- Molecular weight of 530.65
- Chemical formula: C32H38N2O5
- CAS number: 198481-33-3
- Appears as a solid
- Color is white to off-white
- Soluble in DMSO at 50 mg/mL
Medchemexpress LLC Elexacaftor-d3 (VX-445-d3) | 2216712-66-0 | 98.3% | 600.67 | 1 MG
Elexacaftor-d3 (VX-445-d3) is a deuterium labeled compound, serving as a tracer and internal standard for quantitative analysis methods such as NMR, GC-MS, or LC-MS. Deuteration may influence the pharmacokinetic and metabolic profiles of drugs. Its unlabeled counterpart, Elexacaftor (VX-445), acts as a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector, aiming to restore Phe508del CFTR protein function and treat cystic fibrosis.
- Deuterium labeled compound
- Used as a tracer
- Used as an internal standard for quantitative analysis
- Potential to affect pharmacokinetic and metabolic profiles of drugs
- Restores Phe508del CFTR protein function
- Has potential to treat cystic fibrosis
- Improves Phe508del CFTR protein processing, trafficking, and chloride transport
Medchemexpress LLC Aminoadipic acid-d3 | 2483832-01-3 | 99.1% | 164.17 | 10 MG
Aminoadipic acid-d3 is the deuterium labeled Aminoadipic acid, an intermediate in the metabolism of lysine and saccharopine. Deuterium substitution has the potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Cayman Chemical DecnoIc AcId-d3 10mg
An internal standard for the quantification of decanoic acid by GC- or LC-MS
Medchemexpress LLC Acetamide-2,2,2-d3, N-(4-hydroxyphenyl)- | 60902-28-5 | 100.0% | C8H6D3NO2 | 5 MG
Acetaminophen-d3 is the deuterium labeled form of Acetaminophen (Paracetamol), a widely used antipyretic and analgesic agent. It functions as a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM, and also acts as a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor. This isotope-labeled compound is for research use only.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Contains stable heavy isotopes for quantitation during drug development
- Deuteration can affect the pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Cinacalcet-d3 hydrochloride | 364782-34-3 | 97.6% | C22H20D3ClF3N | 500 UG
Cinacalcet-d3 (hydrochloride) is the deuterium labeled Cinacalcet (hydrochloride). It is an orally active, allosteric agonist of the Ca receptor (CaR), used for cardiovascular disease treatment. Deuteration has gained attention due to its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Isotope-labeled compound.
- Endogenous metabolite.
- Inhibitor.
- Targets CaSR and is relevant for cardiovascular disease.
Medchemexpress LLC Velmupressin acetate | 1647120-04-4 | 99.5% | 1006.63 | 10 MG
Velmupressin acetate is a potent, selective, and short-acting peptidic V2 receptor (V2R) agonist. It exhibits high affinity for both human (hV2R) and rat (rV2R) V2 receptors, with EC50s of 0.07 nM and 0.02 nM respectively. This product is intended for research purposes only.
- Potent and selective V2 receptor agonist
- Short-acting peptidic compound
- High affinity for human and rat V2 receptors
- For research purposes only
Medchemexpress LLC Velmupressin acetate | 1647120-04-4 | 1006.64 g/mol | 1 MG
Velmupressin acetate is a potent, selective, and short-acting peptidic V2 receptor (V2R) agonist. It exhibits EC50 values of 0.07 nM for human V2R (hV2R) and 0.02 nM for rat V2R (rV2R). This product is stable under recommended storage conditions and is not classified as a hazardous substance or mixture according to safety data.
- Potent, selective, and short-acting peptidic V2 receptor (V2R) agonist
- EC50 values of 0.07 nM for human V2R (hV2R)
- EC50 values of 0.02 nM for rat V2R (rV2R)
- Stable under recommended storage conditions
- Not a hazardous substance or mixture
- For research use only
Medchemexpress LLC Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-sulfamate | 172377-52-5 | MFCD00947822 | 351.46 | 25 MG
Estradiol 3-sulfamate, also identified as BLE 00084, E2MATE, or ES-J 995, is characterized as a potent, long-acting, and orally active inhibitor of steroid sulfatase.
- Potent steroid sulfatase inhibitor
- Long-acting steroid sulfatase inhibitor
- Orally active steroid sulfatase inhibitor
- Inhibits estrone sulfatase with an IC50 of 251 nM
- Inhibits estrone sulfatase with a Ki of 133 nM
Cayman Chemical 2-bromo 17-EstradIol 50mg
A synthetic steroid and inhibitor of estrogen 2-hydroxylase; inhibits estrogen 2-hydroxylase in rat liver microsomes at 50 and 100 µM; prevents estrogen-induced inhibition of apomorphine-induced climbing behavior in mice at 5 mg/kg
Medchemexpress LLC Lincomycin-d3 | 154-21-2 | 99.9% | 409.56 | 500 UG
Lincomycin-d3 is the deuterium labeled Lincomycin, intended for research use only. This compound serves as a tracer and an internal standard for quantitative analysis methods like NMR, GC-MS, or LC-MS. Deuteration, the incorporation of stable heavy isotopes, has the potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Functions as an internal standard for quantitative analysis
- Deuteration may affect pharmacokinetic and metabolic profiles
- Solid appearance
- White to off-white color
- Protect from light
- Store under nitrogen